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High-temp Antioxidant Dissolved Antioxidants
Jun 22, 2017

High-temp Antioxidant Dissolved antioxidants

Antioxidant metabolites


According to the solubility of antioxidants can be divided into two categories: water-soluble antioxidants and fat-soluble antioxidants. Water-soluble antioxidants are usually present in the cytoplasmic matrix and plasma, and the fat-soluble antioxidant protects the lipid from the cell membrane from peroxidation. These compounds are either biosynthesized in the human body or ingested by dietary intake. Different antioxidants are distributed in body fluids and tissues at a range of concentrations. Glutathione and coenzyme Q10 are predominantly present in cells, and other antioxidants such as uric acid are more widely distributed (see table below). Some antioxidants are present in certain tissues of the body because of both antioxidant and important pathogens and pathogenic factors.

Some compounds chelate with the transition metal to prevent the metal in the cell to promote the generation of free radicals, which play a role in antioxidant defense. A particularly important point in this antioxidant defense is to isolate iron ions through coordination chelates because iron ions are the key to some iron-binding proteins such as transferrin and ferritin The Selenium and zinc are generally thought to be antioxidant nutrients, both of which do not have antioxidant properties but will act on some antioxidant enzymes.

Uric acid

Uric acid is the highest concentration of antioxidants in the blood. Uric acid is the intermediate product of purine metabolism, produced by the oxidation of xanthine by xanthine oxidase, and is an oxypurine with antioxidant activity. In most terrestrial animals, uric acid oxidase can catalyze the further oxidation of uric acid to allantoin, but the human and some senior primate uric acid oxidase gene does not play a role, so uric acid in the body will not be further decomposition. The reason for the loss of uric acid oxidase function in human evolution is still a question to be explored. The antioxidant activity of uric acid has led researchers to speculate that this mutation is beneficial to early primates and humans. The results of the study on the adaptability of biological high altitude environments support the hypothesis that uric acid as an antioxidant can alleviate oxidative stress induced by plateau hypoxia. In the animal experiments of oxidative stress-induced disease, uric acid was found to prevent or alleviate the disease, and the researchers attributed it to the antioxidant properties of uric acid. The results of the study on the mechanism of uric acid oxidation also support this proposal.

For multiple sclerosis, Gwen Scott explains the importance of uric acid as an antioxidant in the treatment of multiple sclerosis. Serum uric acid levels are inversely related to the incidence of multiple sclerosis in patients with multiple sclerosis Of the uric acid level is low, and suffering from gout patients rarely suffer from this disease. More importantly, uric acid can be used to treat experimental properties of allergic encephalomyelitis - an animal model of multiple sclerosis. In short, although the mechanism of uric acid as an antioxidant is well supported, the claim that the level of uric acid in the body affects the risk of multiple sclerosis remains controversial and requires more research.

Uric acid is the highest concentration of all antioxidants in the blood, and half of the total antioxidant capacity in human serum is contributed by it. Uric acid has a very complex antioxidant activity, it can not react with some oxidants such as superoxide, but can peroxynitrite (peroxynitrite), peroxide and hypochlorous acid play an antioxidant effect.